纽约市哥伦比亚大学(Columbia University in the City of New York)

是一所坐落于纽约市曼哈顿上城晨边高地的私立研究型大学,常春藤联盟成员。她被视作世界上最具声望的大学之一。 哥伦比亚大学是美国大学协会的十四个创立成员之一,并且是美国第一所授予医学博士学位的大学。 哥伦比亚大学是每年一度的普利策奖的颁发机构,哥伦比亚大学——包括其前身国王学院——的著名校友包括五位美国开国元勋;九位美国最高法院法官;二十位在世的亿万富翁;二十九位奥斯卡奖获得者;以及二十九位各国元首,包括三位美国总统。九十五位校友、教职工或研究人员是诺贝尔奖获得者,数量在全球所有大学中名列第五。

化学工程科研

一、课题方向

Polymer chemistry

高分子化学

DNA, Nanotechnology

DNA纳米技术

Self-assembly

自组装

Molecular design

分子设计

Modification of material surfaces

材料表面改性

Biophysics and soft matter physics

生物物理学和软物质物理学

 

二、导师背景

杰出研究教授

高分子科学教授

 

三、科研内容参考

课题一:

The Design of DNA Frames by DNA Origami Technology

Keywords: DNA, Nanotechnology, DNA origami

Recommendation: This project will focus on the hottest topic in the field of DNA

Nanotechnology: DNA origami. This is a project designed for students who have background in chemistry and biology. This project is recommended for any students who are interested in the DNA nanotechnology.

Introduction:

Deoxyribonucleic acid ( DNA) is a long polymer made from repeating units called nucleotides. DNA is the most important materials in living organisms for carrying the genetic instructions used in the growth, development, functioning and reproduction. In living organisms, DNA usually exist as a pair of molecules that are held together by the hybridization of base pairs, so called double stand DNA. In addition to their essential functions in biology, DNA is also very attractive for materials scientists and engineers due to their unique properties. In recent years, significant progresses have been achieved in the field of DNA nanotechnology. Among them, the most notable advance is the development of DNA origami, which is a process of molecular self-folding of a long single-stranded DNA into prescribed objects (or DNA frames) by hundreds of short DNA oligonucleotides. With the help of computer, arbitrary shape of DNA frame can be designed and then experimentally realized in the laboratory. These DNA origamis are very useful for many applications including DNA robots, enzyme immobilization and drug carry capsules and so on.

The goal of this project is to ensure students have a good understanding in DNA origami, to be familiar with related DNA nanotechnology. Students will be taught the basic principle of DNA folding and how to design and characterize DNA frame with different shape. In the meantime, students will be provided with the data regarding the characterization of DNA frame. In addition, student will be encouraged to further assemble designed DNA frames into hierarchically complex structures. Students will finally be guided to write a report regarding the design of DNA frames by DNA origami.

课题二:

Polymer Self-assembly toward Nano-coins

Keywords: polymer, self-assembly, mimicking nature

Recommendation: This project will focus on an attractive topic in the field of materials science: polymer self-assembly. This is a project designed for students who have background in polymer and materials science. This project is recommended for any students who are interested in polymer and polymer self-assembly.

Introduction:

Self-assembly is a process in which a disordered system of pre-existing components forms an organized structure as a consequence of specific, local interactions among the components themselves, without external driving force. When the constitutive components are polymers, the process is termed polymer self-assembly. The self-assembly of polymer is critically important is because the properties of polymer materials are intimately related to their hierarchically assembled structures. To develop the polymer materials with better properties, it is necessary to understand how to design polymers and how to self-assemble them into designed structures. Self-assembly is ubiquitous in nature from cell membrane to complex living organism. Using polymer to mimic the self-assembly process in nature and develop advanced materials is one of the hottest and most promising topics in the materials science.

In this project, we will focus on the fabrication of two dimensional “nano-coins” by polymer self-assembly, mimicking the thylakoid of chloroplast in nature. The goal of this project is to ensure students have a good understanding on polymer self-assembly. Students will be taught the basic principle in polymer self-assembly and how to design polymer and characterize polymer self-assembled structures. In the meantime, students will be provided with the data regarding the characterization of polymer self-assembled structures. Students will finally be guided to write a report regarding the self-assembly of two-dimensional “nano-coins”.

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